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Microbial metabolites in multiple sclerosis: Implications for pathogenesis and treatment

DISCUSSION Endothelial dysfunction and impaired NO signaling are common contributors to ED [8]

199,200 In addition, for Cu bis(thiosemicarbazone) analogs, the anticancer activity of Cu II (atsm) has been demonstrated in hamsters bearing colon cancer tumors, 201 and Cu II (gtsm) has been shown to exert tumor-killing effects on prostate cancer cells in vitro and significantly reduce the prostate cancer burden in an orthotopic mouse model