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J Orthop Res 2003;21:976-983

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From a CPMG-based LO-NMR fragment screen, we identified one naphthalene sulfonic acid fragment hit ( 27 ) that binds to TRF1 TRFH with triple-digit micromolar affinity as measured by the R2KD assay

By engaging these two GPCR targets, it synergistically reduces food intake beyond what native amylin achieves

Experimental evidence suggests an involvement in vascular remodeling through stimulation of new microvessel development, alongside regulation of nitric oxidedependent signaling