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Although no direct ligand has been identified for HER2/neu, it can be activated through overexpression or transactivation by ligands of other EGF family receptors (60, 61) In addition, the phosphatase protein tyrosine phosphatase 1B (PTP1B) regulates tyrosine kinase signalling by dephosphorylating key kinases involved in breast tumourigenesis, including HER1/EGFR, proto-oncogene tyrosine-protein kinase (Src), janus kinase (JAK), and signal transducer and activator of transcription (STAT)

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They appear to synthesize neuropeptides (e.g., substance P) that influence the central and peripheral nerve terminals

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This oxidative stress, likely driven by altered neurotransmitter signaling and cellular metabolism, is thought to contribute to schizophrenia-related deficits in inhibitory interneuron populations, including parvalbumin-positive cells (Li et al., 2024)