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By mapping Chr21, the APP gene encodes the amyloid precursor protein and the EST2 gene encodes a transcription factor that further promotes the expression of APP , resulting in increased production of A oligomeric toxic peptides, which form the backbone of amyloid plaques (463)

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Reduced inflammatory cytokine activity, improved microvascular integrity, and beneficial effects on pain modulation through peripheral and dopaminergic mechanisms are among the reported effects in animal studies

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Thats why subcutaneous injection of large doses (5-10 mg) is the standard delivery method in most epithalon protocols: you have to flood the system to get enough surviving peptide into target tissues before degradation wipes it out