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These data strongly suggest that therapeutic strategies aimed at preserving the health and function of the vascular niche, particularly the sinusoidal endothelium, could represent a novel and targeted approach to mitigate age-related hematopoietic decline and potentially delay the onset of hematologic diseases

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Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus