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Kumar et al., 2009) characterized by polydipsia (increased thirst), polyuria (frequent urination), and polyphagia (increased hunger) with consequences of homeostasis disruption because of impaired glucose metabolism

Upon uptake by liver cells via CTR1, copper can be integrated into newly synthesized ceruloplasmin or transferred to intracellular chaperone proteins for further distribution

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Hepatocytes in particular demonstrate marked upregulation of the canonical Notch target gene, HES1 , compared to nonparenchymal cells, correlating with disease severity (132)

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Note that, while the level of IFN- in human serum is almost nil in the absence of infection, there is a low but detectable level of IFN- in bat serum (102, 103)