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MATERIALS AND METHODS We performed a systematic review of the literature, using Ovid MEDLINE databases and reference lists of retrieved articles

Its a necessary building block for hormones, cell membranes and other key functions in the body

This enzyme converts L-arginine into nitric oxide and L-citrulline

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Retrovirus-mediated expression of apolipoprotein A-I in the macrophage protects against atherosclerosis in vivo

Liquid chromatography-tandem mass spectrometry was employed to quantify plasma TMAO, choline and their related metabolites, encompassing TMA, l-carnitine, betaine and dimethylglycine (DMG), which are betaine-related metabolites (Reference Wiedeman, Barr and Green14)