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And that didn't happen until liposomal technology emerged in the late 1990s

83 AKT-mediated FOXO inhibition prevents VEGF suppression while enhancing Sp1-driven VEGF transcription

J Cell Physiol 233(1):8897

Preneoplastic and neoplastic progression during hepatocarcinogenesis in mice injected with diethylnitrosamine in infancy

They include human bocavirus (HBoV), human coronaviruses (HCoV-HKU1, -NL63), human metapneumovirus (HMPV), rhinovirus type C (RV-C), and human polyomaviruses (KIPyV, WUPyV), as well as SARS coronavirus (SARS-CoV), MERS coronavirus (MERS-CoV), novel strains of influenza virus A and B, and, most recently, SARS coronavirus 2 (SARS-CoV-2)