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The symptoms of B12 deficiency can vary widely and may include fatigue, weakness, tingling or numbness in the hands and feet, difficulty concentrating, and even mood disturbances

biologic therapy initiation Severe/fulminant: IV corticosteroids (methylprednisolone 4060 mg/day IV)

Adequate levels of B12 support metabolism in three key ways: B12 breaks down nutrients from food and turns them into usable energy

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In a 72-week study of adults with diabetes, average weight loss was 12.8% for 10 mg, 14.7% (33 lbs) for 15 mg, and 3.2% (7 lbs) for placebo