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Thus, they are likely gain-of-function variants in which a background cation leak leads to cellular hyperexcitability, as generally is reported in other dominantly-inherited channelopathies (85)

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Statistically, in healthy individuals, about 12 h after ED ingestion, there is an increase in systolic blood pressure by 610 mmHg, diastolic blood pressure by 36 mmHg, heart rate by about 37 beats/minute, and QT interval prolongation up to 2225 ms