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This pulsatile character is considered experimentally important: the liver and peripheral tissues respond differently to pulsatile versus continuous GH exposure, and several of GH's anabolic and lipolytic effects are specifically dependent on the pulse pattern rather than mean concentration

Texas A&M University

Rapid fat loss removes volume beneath the skin faster than the skin itself can contract, leading to sagging

He received 48.6 percent of the vote, 17 points ahead of the runner-up, Cruz Bustamante of the Democratic Party

Dual molecular effects of dominant RORA mutations cause two variants of syndromic intellectual disability with either autism or cerebellar ataxia