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Furthermore, a significant increase in HMGB1 levels was detected in the ZDS NPs group compared to the ZD NPs group, providing evidence that ROS resulted in the release of additional HMGB1 and thereby inducing ICD effect

The PDIs of the various formulations varied from 0.255 0.07 (F1) to 0.419 0.03 (F4), suggesting the homogeneity of the prepared formulations till 4 mg % CS