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Second, published human clinical-trial data is sparse

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[The Working Group noted that the reported effects were adjusted for BMI.] In another cross-sectional study that aimed to characterize the relationship between dietary sweeteners and metabolic dysregulation and cardiovascular disease in a cohort of people who were or were not infected with human immunodeficiency virus (HIV), aspartame consumption in the HIV-positive group ( n = 36) was positively (but non-significantly) associated with the inflammatory markers lipoprotein-associated phospholipase A2 (Lp-PLA2

Data show concrete evidence of the existence of a bidirectional communication between the gut and brain (Mayer et al., 2022), gut and kidney (Evenepoel et al., 2017), and kidney and brain (Xie et al., 2022)

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