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In another aspect of the invention, a method of targeted drug delivery of an effective amount of an agent, or a pharmaceutical acceptable carrier comprising an agent, to a target site that is protected by a specific blood-tissue barriers like e.g., the CNS, the blood-brain barrier (BBB), the retina and the testes, is provided wherein: a) the agent or the pharmaceutical acceptable carrier is conjugated to a ligand, that facilitates the specific binding to and internalization by an internalizing GSH uptake receptor of the target site, thereby forming the conjugate as defined above

While dimerization and oligomerization of integral membrane proteins remained a generally accepted concept, translating this to GPCRs remained elusive (Klingenberg, 1981)

A de novo convergence of autism genetics and molecular neuroscience

Patient Assistance Program Application and Guidelines

Environ Exp Bot 56:8794 Baek KH, Skinner DZ (2003) Alteration of antioxidant enzyme gene expression during cold acclimation of near-isogenic wheat lines

This finding has led to modifications in behavioral activation therapy protocols to emphasize effortful activities that generate natural dopamine responses