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It is crucial to note, however, that recent studies highlight significant systemic side effects of MCT4 inhibition due to its broad tissue expression, which may limit its clinical translational potential and necessitate the development of tissue-specific delivery strategies [138]

ROS encompass a range of highly reactive molecules, including singlet oxygen (1O2), hydrogen peroxide (H 2 O 2 ), and free radicals like the hydroxyl radical (OH) and superoxide anion (O2-)

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