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Horowitz M, Purdy PD, Burns D, Bellotto D

f - h , Metagene profiles of m 6 A peaks across transcripts ( f ), distribution of m 6 A peaks across transcript regions ( g ), and enriched sequence motifs at m 6 A sites ( h ) identified from MeRIP/m 6 A-seq data generated as in ( e )

Together, these data support the conclusion that the primary impact of the S10D mutation is on IRGQ engagement and the basal organization of ATG8-positive structures, rather than on global autophagy induction or lysosomal delivery of LC3 under stress

They contribute significantly to various aspects of brain function, including brain development, learning and memory processes, and the maintenance of CNS homeostasis