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10.1016/S0140-6736(02)11667-9 101 RyterS

Nature Aging, 1(10), 1086-1099.

J.ShowlerA

Based on the effects of Cr on IGF-1 levels and IGF-1 signaling, we further discussed the mechanism of IGF-1 in suppressing neuroinflammation to explain the potential anti-neuroinflammation of Cr

In addition, spermidine has been shown to reduce the accumulation of ROS and enhance the activity of antioxidant enzymes such as SOD and catalase, thereby mitigating oxidative damage at the cellular level (Reference Jeong, Cha and Han21)