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For SARS-CoV-2 M pro we used our novel tetrapeptide QS1 fluorogenic substrate, that has a lower k cat /K M value (k cat /K M = 859 s 1 M 1 ) in comparison to FRET substrates 22

Therefore, in future research, it is necessary to conduct further in vivo animal experiments to gain a better understanding of the formulations performance in living systems and evaluate its potential effects in treatment or other applications.In contrast to conventional cancer therapies, nanomaterials-mediated drug delivery offers superior efficacy, decreased toxicity, and ligand-specific targeting, thus managing cellular toxicity and improving cost-effectiveness

(1998) is the only published head-to-head comparison

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In contrast, deacetylation of lysine residues by HDACs may cause compression of the DNA/histone complex and suppress gene expression