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In malignant tumors, IFN produced by CD8+ T cells increases with rising Gln concentrations, indicating that immunotherapy targeting tumors also relies on Gln-dependent activation of CD8+ T cells ( In the microenvironment of liver cancer tumors, Gln deficiency promotes the invasion of myeloid cells expressing the immunosuppressive receptor GPR109A, facilitating immune evasion

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One prospective study of low-risk individuals, looking at the heart, lungs, liver, kidneys, pancreas and spleen, noted that 70% of 201 patients had damage to at least one organ and 29% had multi-organ damage 69

doi: 10.7150/ijms.91940 Summary Keywords lung cancer, ferroptosis, cell death mechanisms, tumor microenvironment, therapeutic strategies, molecular pathways Citation Gao G and Zhang X (2025) Broadening horizons: research on ferroptosis in lung cancer and its potential therapeutic targets