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6,596,701, references that replacement of deficiencies of the constituent components related to the formation of S-adenosyl methionine will aid in the restoration of health related problems, but there is no reference for the use of the combination of glutathione alone or in combination with methylcobalamin to restore the function of the methionine cycle

Similarly, a post hoc analysis of an RCT, evaluating the efficacy of combination therapy versus monotherapy with different mechanisms of action, found no significant differences

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