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The methodological quality of individual trials was also assessed according to a) whether randomization was concealed, b) blinding, c) analysis was based on the intention-to-treat (ITT) principle, d) patient selection, e) comparability of groups at baseline, f) extent of follow-up, g) description of treatment protocol and co-interventions, and h) definition of clinical outcomes

The trial was continued for two years, even though the treatment group was only given NAC for 832 weeks (median 24)

Hoque TS, Hossain MA, Mostofa MG, Burritt DJ, Fujita M, Tran LSP (2016) Methylglyoxal: an emerging signaling molecule in plant abiotic stress responses and tolerance

Severe gastrointestinal conditions: Those with delayed gastric emptying, gastroparesis, or chronic GI dysmotility may experience exacerbated symptoms due to the drugs action on gastric motility

doi: 10.1038/s41586-018-0449-8 30 RodgersJTKingKYBrettJOCromieMJCharvilleGWMaguireKKet al

Previous studies on DtxR showed that almost all mutations that destroy the DNA-binding properties are located on the metal binding site or helix H3