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Biodegradability testing using standardized protocols demonstrates that green-synthesized nanomaterials typically degrade 35 times faster than conventional alternatives, reducing long-term environmental accumulation [54,55,56,57,58]

Once reconstituted, the compound is exposed to hydrolysis, oxidation, and potential microbial contamination, all of which degrade it over time (1)

Such tests include x-rays (with contrast material such as barium), colonoscopy, and endoscopy

The mechanisms involve reducing oxidative stress and inflammation by modulating ROS, AP-1, MMP-1/3, IL-1, SOD, CAT, GSH-Px, TGF-1, Smad2/3, and increasing pro-collagen I expression [25]

J Natl Cancer Inst Monogr 2011:128133 Davern I, Timothy J, James LP, Hinson JA, Polson J, Larson AM, Fontana RJ, Lalani E, Munoz S, Shakil AO, Lee WM (2006) Measurement of serum acetaminophen-protein adducts in patients with acute liver failure

doi: 10.3389/fnut.2026.1822840 Received 04 March 2026 Revised 27 April 2026 Accepted 29 April 2026 Published 20 May 2026 Corrected 28 May 2026 Volume 13 - 2026 Edited by Camelia Munteanu, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, Romania Reviewed by Yasutaka Shigemura, Tokyo Kasei University, Japan Cornelia Witthft, Linnaeus University, Sweden Updates Copyright 2026 Haarhuis, Ahn-Jarvis, Savva, Day-Walsh, Ferns, Hughes, Triller, Al-Jaibaji, Philo, Acaroz, Perez-Moral and Kroon