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Am Rev Respir Dis 148 : 11741178 Schmidt R, Luboeinski T, Markart P, Ruppert C, Daum C, Grimminger F, Seeger W, Gunther A 2004 Alveolar antioxidant status in patients with acute respiratory distress syndrome

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Abrine, an IDO1 inhibitor, suppresses the immune escape and enhances the immunotherapy of anti-PD-1 antibody in hepatocellular carcinoma

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It's also used to treat certain nerve-related conditions, such as optic neuropathy (damage to the optic nerve)

Currently developed DPP1 inhibitors are all oral formulations, while many NSP inhibitors require inhalation administration ( However, DPP1 inhibition also has some potential disadvantages, including slower onset (approximately 20 days to achieve maximum effects) and possible systemic side effects such as hyperkeratosis and periodontitis