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A careful clinical history especially one that includes tick exposure, co-infection risk, autonomic symptoms, and neurologic complaints can significantly affect the diagnostic process

216 In addition, PRMT4-catalyzed asymmetric dimethylarginine (ADMA) has been reported to bind to NOS as a ligand, leading to NOS dysfunction, resulting in decreased cerebral blood flow and aggravating AD, which can be reversed by inhibition of PRMT4

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates

Patel explained

Because exercise improves brain function and gut microbiome composition, its brain-protective effects in AD may be partly mediated through the microbiome