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Notably, systemic inflammatory disorders are associated with the progression of PD

However, the actual mechanisms are not fully understood, and a lack of standardised dosing protocols plus safety concerns like liver dysfunction and anaphylaxis have been reported

While OCM nutrients interventions displayed promise, current human studies were mainly conducted among participants with different underlying medical conditions or middle-aged and elderly populations who may have already had disease onset

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Eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid (PUFA), is anti-inflammatory and has an inverse relationship with inflammatory markers and depression (89)

This lipid overload renders hepatocytes vulnerable to oxidative injury through enhanced generation of reactive oxygen species (ROS), mitochondrial respiratory dysfunction, and endoplasmic reticulum stress