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This possibility of a hypothalamic ghrelin-GHRH interaction appears to be reinforced by the finding of ghrelin in the hypothalamic arcuate nucleus from where it increases GHRH release and antagonizes the inhibitory effects of SS (83) ( Figure 4A )

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10.1016/j.gastro.2005.05.002 74

Attenuated Salmonella typhimurium strains with controlled LPS production (306) limit systemic toxicity while retaining LPSs ability to activate TLR4 in the TMELPS triggers DC maturation and IL-12 production, boosting CD8 + T cell recruitment