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doi: 10.1089/acm.2005.11.601

Interestingly this mutation is located in a residue next to the LNCaP prostate cancer cell line mutation Thr878Ala (139, 225), supporting the view that this region in the ligand binding domain of the androgen receptor is very susceptible to mutagenesis in prostate cancer, which may lead to the tumor becoming resistant to hormone-based therapies

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