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The increasing reliance of adolescents on vitamin D for calcium homeostasis and the detrimental effects of inadequate sun exposure or obesity-related vitamin D deficiency on bone mineral density are being acknowledged as significant public health concerns

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1 Introduction 1.1 Literature review methodology This review was conducted by searching PubMed, Scopus, and Google Scholar databases using the keywords Parkinsons disease, -synuclein, dopaminergic neurons, LRRK2, mitochondrial dysfunction, comorbidities, levodopa, and neuroinflammation. Studies published in English between 2000 and 2025 were included

doi: 10.1016/j.jgr.2022.08.004, 128 SiopiE.GalerneM.RivagordaM.SahaS.MoigneuC.MoriceauS.et al

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A rational approach might combine, for example, a peripherally acting agent to reduce cochlear damage with a centrally delivered anti-inflammatory agent and a cognitive-behavioral intervention to address the associated distress