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P., Cao, P

Novel machine learning techniques could free technicians from tedious laboratory examination, but this line of scientific inquiry needs further development and rigorous validation

Drosophila and mice with the Y314S variant both showed degeneration of dopaminergic neurons and locomotor defects ( In addition to regulating cIII activities, UQCRC1 is also anti-apoptotic

This type of phosphorylation induces apoptosis and ferroptosis in cells exposed to various stress (Zhang et al., 2022)

Third, clinical efforts should include establishing multicenter FRDA biobanks to validate associations between ferroptosis biomarkers (such as ACSL4 and mitochondrial iron content) and clinical measures including SARA ataxia scores and left ventricular ejection fraction, and conducting combination trials of ferroptosis inhibitors with ironsulfur cluster metabolism regulators to evaluate synergistic improvement in neurologic and cardiac function

Therefore, understanding the molecular mechanisms underlying MQC disruption in EMs is important for identifying therapeutic targets