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J Neurosci 23:508895, PMID: 12832532 Dallas M, Boycott HE, Atkinson L, Miller A, Boyle JP, Pearson HA, Peers C (2007) Hypoxia suppresses glutamate transport in astrocytes

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[DOI] [PMC free article] [PubMed] [Google Scholar] 81.Philippot G, Hosseini K, Yakub A, Mhajar Y, Hamid M, Buratovic S, et al

Lower scores mean the patient has fewer deficits and better function

This cytokine signals in an autocrine/paracrine manner through the TNF receptor to activate the mitogen-activated protein kinases p44/42 and JNK that, in turn, downregulate perilipin mRNA and protein expression (104, 105)

However, individuals with MTHFR polymorphisms or low baseline homocysteine metabolism may benefit from precautionary methyl donor support