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This was achieved by a single 50 mg/kg ip dose of the drug and it was reported that inhibition was reached within 10 min of drug intake

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10.1038/353273a0 37 BersukerK.HendricksJ

In Vitro evaluation of the anti-pancreatic cancer activity of epimedium herb

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Maaike H M Oonk, Brian Slomovitz, Peter J W Baldwin, Helena C van Doorn, Jacobus van der Velden, Joanne A de Hullu, Katja N Gaarenstroom, Brigitte F M Slangen, Ignace Vergote, Mats Brnnstrm, Eleonora B L van Dorst, Willemien J van Driel, Ralph H Hermans, David Nunns, Martin Widschwendter, David Nugent, Cathrine M Holland, Aarti Sharma, Paul A DiSilvestro, Robert Mannel, Dorry Boll, David Cibula, Al Covens, Diane Provencher Ingo B Runnebaum, David Luesley, Patricia Ellis, Timothy J Duncan, Ming Y Tjiong, Derek J Cruickshank, Preben Kjlhede, Charles F Levenback, Jiri Bouda, Katharina E Kieser, Connie Palle, Nicola M Spirtos, David M OMalley, Mario M Leitao, Melissa A Geller, Kalyan Dhar, Viren Asher, Karl Tamussino, Daniel H Tobias, Christer Borgfeldt, Jayanthi S Lea, Jo Bailey, Margareta Lood, Brynhildur Eyjolfsdottir, Stephen Attard-Montalto, Krishnansu S Tewari, Ranjit Manchanda, Pernille T Jensen, Par Persson, Linda Van Le, Hein Putter, Geertruida H de Bock, Bradley J Monk, Carien L Creutzberg, Ate G J van der Zee