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Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes

Carnitine is an indispensable metabolite in energy production because transports fatty acids into the mitochondria for beta-oxidation and subsequent ketone bodies formation or Adenosine triphosphate (ATP) generation through the tricarboxylic acid (TCA) cycle (54)

Tumor Biol 35:269275

The authors showed how QU preserves the integrity of the endothelium barrier, enhances bloodlabyrinth barrier (BLB) permeability, inhibits CP-induced oxidative stress, protects mitochondrial function, lowers the apoptotic mitochondrial pathway of the PCs, and activates the PI3K/AKT signaling pathway

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[DOI] [Google Scholar] 294.Mohammed N.K., Abd Manap M.Y., Tan C.P., Muhialdin B.J., Alhelli A.M., Hussin A.S.M