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Immune activation and mitochondrial dysfunction in both central and peripheral immune cells (like microglia in the brain and monocytes in blood) are implicated in these cognitive complications (64)

Similarly, an animal model of diabetes-induced HF showed altered expression levels of copper transporter proteins and disturbed copper metabolism in rat cardiomyocytes (67)

Conclusion and prospects According to the World Obesity Atlas 2024, obesity prevalence among Chinese adults and children continues to rise, positioning obesity as a critical global health challenge across all age groups

Silvin et al., 2022) in human specimen and translational murine models (Figure 1, Table 1)