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Description

Growth hormone production peaks in adolescence and declines through adulthood, and IGF-1, the downstream messenger that drives muscle protein synthesis and tissue repair, declines along with it

doi: 10.1021/acscentsci.3c01340

And different downstream effects mean a different side effect profile

a 2025 literature-and-patent review in Pharmaceuticals summarizes its multifunctional, mostly-preclinical profile (PMC11859134)

Cellular senescence: all roads lead to mitochondria

Induction of neurite outgrowth in PC12 cells by alpha-phenyl-N-tert-butylnitron through activation of protein kinase C and the Ras-extracellular signal-regulated kinase pathway