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In support of this notion, indirect calorimetry revealed an increase in the respiratory exchange ratio (RER) of p53 KO mice during the refeeding phase (Fig

PX-478 effectively suppressed HIF-1 and downstream NIX protein expression in a dose-dependent manner (Supplementary Fig

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5.3 S-acylation in -cells S-acylation has been shown to be an important regulator of ion channels, vesicle trafficking, and small GTPAses, controlling many aspects of protein sorting, membrane localization, and lipid metabolism ( ATP channel activity is strongly modulated by S-acylation, which causes channel opening, counteracting the ability of ATP to close the channel ( 2+ channels ( 2+ influx and insulin exocytosis ( Figure 2 )

Notably, genera such as Neisseria , Lautropia , and Agrobacterium were elevated, along with associated toxic serum metabolites, including 4-chlorophenylacetic acid, 5-sulfoxymethylfurfural, and estradiol valerate, which may contribute to gastrointestinal disturbances