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The long-term exposure of -cells to IL-1 and IL-6 may lead to apoptosis, resulting in insulin resistance and increased glucose levels in the blood [37]

When the concentration of ammonia increases, glutamic acid synthesis increases, and glutamic acid and ammonia synthesis glutamine increase, which will affect the energy metabolism process of cells and consume ATP, and the activity of Na+-K+ -ATPase is inhibited by ammonia, ATP production is reduced, energy source of the brain is reduced, and the body will eventually appear coma 26

[DOI] [PubMed] [Google Scholar] 27.Richie J.P., Jr., Abraham P., Leutzinger Y

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