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The present studies reveal that the inflamed synovium in RA would similar properties of enhanced permeability and retention (EPR) effect as in solid tumors-like

To mitigate oxidation, raw materials must be free of reactive impurities such as transition metal ions and peroxides [159]

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For instance, surface modification with Tet-1 peptide facilitates blood-brain barrier penetration for glioblastoma and Alzheimers therapy, while PLGA-TPGS (d--tocopheryl polyethylene glycol succinate) nanoparticles exhibit preferential accumulation in hepatocellular carcinoma (HepG2) cells, significantly improving antitumor efficacy and reducing systemic toxicity in vivo [98, 99]

Briefly, following log transformation and imputation with minimum observed values for each compound (described previously in 5456), Welch's twosample t test was used to identify biochemicals that differed significantly between control liver tissue and tumor tissue