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The coabundance of creatine, adenine, and succinate markers of impaired epithelial bioenergetics, barrier-damage, and regional hypoxia has important implications

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[DOI] [PMC free article] [PubMed] [Google Scholar] Martinez-Garcia M.A., Faner R., Oscullo G., De La Rosa D., Soler-Cataluna J.J., Ballester M., Agusti A

The three proline residues at positions 35 (the PPP motif) rigidify the chain and hinder access by proteolytic enzymes a molecular explanation of the peptide stability in the gastrointestinal environment described in the literature