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Early NRTIs such as Zidovudine (AZT), Stavudine (d4T) and Didanosine (ddI) had a higher affinity for Pol- and consequently produced substantial mitochondrial toxicities, including lactic acidosis, hepatic steatosis, peripheral neuropathy, and lipoatrophy (104, 105)

In these patients, the translocation of gut-derived endotoxins, such as lipopolysaccharides (LPS), into systemic circulation is a recognized contributor to systemic inflammation and subsequent BBB compromise (Gofton and Young, 2012)

The weights were calculated as follows: N states refers to the number of possible states for a given GPR, which is calculated as 2 n with n being the number of genes in a GPR

10.1007/s00213-014-3687-y Psychopharmacology (Berl)

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FIGURE 1 5 Exogenous source of antioxidants with therapeutic potential At present, there are many types of antioxidants in use, including essential oils (EO) ( 5.1 Antioxidants for neurological disorders Neurological diseases such as Alzheimers disease and epilepsy, due to their complexity and severity, present numerous challenges in clinical treatment