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Among OAPs, only clozapine was associated with a significantly lower risk of treatment failure when compared to LAI aripiprazole (Q1M) and LAI haloperidol (Q1M), but no different than LAI risperidone (mainly Q0.5M)

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Figure 2 Oxidative insult and male hormones in reproduction The occurrence of oxidative stress depends on either the overproduction of ROS or depletion of antioxidants, which may result in lipid peroxidation in Leydig cells and germ cells and is detrimental to lipoproteins, protein aggregation and fragmentation, and steroidogenic enzyme inhibition (43)

Mol Cell (2019) 75:114760.e5

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