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Brain endothelial GSDMD activation mediates inflammatory BBB breakdown

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Furthermore, a recent study showed that patients with diabetes exhibit significantly lower levels of GPX4 enzyme in their heart, than age-matched nondiabetic patients 37

Therefore, H 2 O 2 -induced oxidative stress recapitulates the developmental bias of GPX2 KO, and Se treatment rescues this phenotype by restoring the expression of pancreatic and liver markers in KO cells

Firstly, it can damage healthy tissues, including cartilage and myelin, which is the nerves protective sheath