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Crosstalk between chaperone-mediated protein disaggregation and proteolytic pathways in aging and disease

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Skin purging happens when new skincare products speed up cell turnover, bringing impurities to the surface

Upregulation of CD38 in patients with SSc, resulting from its induction by cytokines such as TGF-, IL-6 and senescent cell-derived SASP enriched in the fibrotic tissue microenvironment, will promote NAD + consumption and decline, which in turn impairs the function of sirtuins and other NAD + -dependent cellular enzymes