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Dhuria SV, Hanson LR, Frey IIWH

DOI: 10.1002/9780470744307.gat166

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Physiological and pathological functions of NADPH oxidases during myocardial ischemiareperfusion

In fact, MitoQ has been used in a range of in vivo studies, in rats and mice, and in two phase II human trials demonstrating that it can be safely delivered to patients with promising results, lending further support that mitochondria-targeted antioxidants may be applicable to a wide range of human pathologies that involve mitochondrial oxidative damage (Smith and Murphy, 2010)

Conducting studies with oral formulations might require more foundational research to establish optimal parameters, adding layers of complexity to experimental design