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This precision medicine approach potentially enables clinicians to individualize treatment regimens through the selection of the best strain, dose, and combination therapies to maximize efficacy and minimize toxicity

Although the gcs1 and glr gene expression levels were not significantly different in ATCC18224 strain, we detected differential expression levels of these genes in the ATCC200051 strain background

Methods Enzymol 348:281288 Garcia-Nogales P, Almeida A, Fernadez E, Medina JM, Bolanos JP (1999) Induction of glucose-6-phosphate dehydrogenase by lipopolysaccharide contributes to preventing nitric oxide-mediated glutathione depletion in cultrued rat astrocytes

Under conditions of excessive glucose availability, the cells metabolic capacity is overwhelmed, leading glucose to flow into alternative metabolic pathways, including glyceraldehyde autooxidation, diacylglycerol synthesis with protein kinase C activation, and hexosamine biosynthesis, which further amplify oxidative stress through excessive ROS formation [14]

Astrocyte-induced synapse formation and ischemic stroke

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