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Unlike mitragynine, 7-hydroxymitragynine had little to no binding affinity to both alpha-1 and alpha-2 adrenoreceptors indicating that oxidation at the C-7 abolishes the interaction with these receptors

npj Metab Health Dis 2 , 31 (2024)

Given the industrys experience in the development of mAbs, most available literature heavily features mAbs in training data for complex deep-learning and other kinds of statistical models