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Furthermore, macrophages clear immune complexes produced by B cells via Fc receptors, preventing their deposition in the joint and reducing tissue damage (145)

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While established platforms like the MCP-MS2 system have successfully packaged PSA mRNA and circRNA for sustained antigen expression, the sensitivity of the protein-RNA assembly interface remains a primary bottleneck for industrial scale-up, necessitating rigorous, platform-specific empirical tuning (Gupta et al., 2024