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10.1016/j.bcp.2024.116603 284 Perez OrtizJ

This reaction depends on the catalytic selenocysteine residue of GPX4, which is directly targeted and inactivated by ferroptosis inducers such as RSL3

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2013;55:50-61.[DOI] 54

ISSN 0953-7562

In further support of the KRAS G13D -specific HER2-HER3 dependence, GSEA of both our RNA-seq data and GSE39582 dataset revealed strong positive enrichment of the PI3K/AKT signaling pathway signature in HER2 high KRAS G13D cases, with notably elevated NES values (Supplementary Fig