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They did this by using a subcutaneous tumorigenic model in nude mice

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Diagnostic categories were associated with emotional distress (b=5.630, SE=2.078, p=0.008), with the adjusted mean distress scores highest in individuals with dementia (M=19.722, SE=2.488), followed by MCI (M=19.640, SE=2.685), and those who are cognitively normal (M=9.380, SE=3.065)