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A cross-sectional study of 700 community-living, physically disabled women over the age of 65 found that vitamin B 12 -deficient women were twice as likely to be severely depressed as non-deficient women (97)

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Additional risk factors include having your gut operated on, pancreatic insufficiency, small intestinal bacterial overgrowth (SIBO), parasite infections, and certain autoimmune disorders

In two similar, randomized, placebo-controlled trials performed by one research group, six months of treatment with 2 mg folic acid, 25 mg B6, and 400 mcg B12 per day reduced the frequency of migraines better than placebo in women with migraines with aura, but 1 mg folic acid plus the same doses of B6 and B12 did not (Menon 2012

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