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In the light of a recent cohort study by Tang and his colleagues, comprising 4,000 individuals for 3 years, it has been found that TMAO can be a new biomarker for cardiac mortality, MI, or cerebrovascular accidents in addition to increasing cardiac-related mortality by 2.5 times [73, 74]

Dietary choline is the most logical and likely explanation, but may not be the only one

(PubMed) Smith WA, Fry AC, Tschume LC, Bloomer RJ

[DOI] [PMC free article] [PubMed] [Google Scholar] Hanganutziu M

Larazotide acetate promotes tight junction assembly in epithelial cells

Characteristics of PCD include low carnitine levels in the blood, reduced carnitine reserves within cells, and an increase in carnitine loss through the urine